Drug Standardisation Research

Since 2011, the Drug Standardization Unit has been actively engaged in:

  • Standardization of Single Drugs (various plant parts such as roots, leaves, stems, and rhizomes).
  • Physico-chemical Evaluation of Finished Formulations (Churna, Taila, Ghrita, Capsules, Tablets).
  • Chromatographic Fingerprinting (TLC/HPTLC) and marker-based profiling for quality assurance.
  • Development of Standard Operating Procedures (SOPs) and Shelf-life Studies for Ayurvedic formulations.
  • Phytochemical isolation and characterization of active marker compounds from medicinal plants.

Major Accomplishments and Projects

  • Initiated standardization work on Amalakyadi Churna, Balacaturbhadrika Churna, Rasna Saptakam, and Jwarahara Churna (2011–2012).
  • Analyzed 176 samples of 53 single drugs and 48 samples of 14 formulations (2012–2013).
  • Completed physico-chemical analysis and API standardization of Neem Oil and Nimbatiktam powder/capsule.
  • Developed and prepared Nimbatiktam 200 mg Capsules under the CCRAS Project (2013–2019), supplying 3,000 capsules to peripheral institutes and 6,000 capsules to headquarters.
  • Between 2020–2025, analyzed over 1,500 samples covering 30 formulations and Ayush/herbal drugs for selected quality parameters.
  • Conducted isolation of marker compounds such as Curcumin, Embelin, Asiaticoside, and Arjunolic Acid from Curcuma longa, Embelia ribes, Centella asiatica, and Terminalia arjuna, respectively.
  • Maintains a Herbarium Repository of authenticated medicinal plant specimens for research and reference.

Ongoing IMR and Collaborative Projects

  1. QC Analysis, Marker Estimation, and Shelf-Life Studies of Ayush M3 and Ayush SS Granules.
  2. QC analysis and Estimation of Markers of Jwarahara Kwatha Choorna (JKC) for fever management.
  3. Development of SOP and Marker Estimation in Tryushnadi Guggulu – a classical Ayurvedic formulation.
  4. Development of Quality Control Protocols for medicated oils: Murivenna, Durvadikera, Bhringamalakadi Kerataila.
  5. SOP Validation and Shelf-Life Study of MML Taila.
  6. Evaluation of Brahmi Ghrita in in-vitro and in-vivo models for Alzheimer’s disease.

Pharmaceutical Development and Characterization of Karuthamarmani Gutika and Shirostodadi Gutika/Tablets.

Key Achievements

  • Developed and standardized Nimbatiktam 200 mg Capsule formulation.
  • Submitted CTD Monograph on Piper longum to CCRAS.
  • Completed standardization of Ayurvedic oils, powders, and single drugs for pharmacognostic and analytical profiling.
  • Isolated and characterized key bioactive marker compounds from medicinal plants under IMR projects.

Completed  Drug Standardization Research

S.No.

Project Name

1.        

Isolation of maker compounds of some selected medicinal plants

2.        

Preparation of Nimbatiktakam Capsules

3.        

QC Analysis and Estimation of  Markers in polyherbal formulation ‘Jwarahara Kwatha Choornam (JKC)’ for the effective treatment of fever

4.        

QC Analysis, Estimation of  Markers/PRS & shelf life studies of AYUSH M3 and AYUSH SS Granules

5.        

Development of SoP, Estimation of maker compounds in polyherbal formulation: Tryushnadi Guggulu-A Classical Ayurvedic formulation

6.        

Development of quality Control protocols, identification, and estimation of  major bioactive  constituents of Ayurvedic Medicated oils ‘Murivenna’, ‘Durvadi kera’,Bhringamalakadi  Kerataila

7.        

Pharmaceutical Standardization of Polyherbal Formulations MML Taila with Shelf-Life Study.

8.

Pharmaceutical development and characterization of karuthamarmani gutika/tablet/shirastod adi gutika/ table